Neurobiology of Disease The Complement Receptor C5aR Controls Acute Inflammation and Astrogliosis following Spinal Cord Injury
نویسندگان
چکیده
Faith H. Brennan,1 Richard Gordon,1 Hong W. Lao,1 Patrick J. Biggins,1 Stephen M. Taylor,1 Robin J.M. Franklin,2 X Trent M. Woodruff,1 and Marc J. Ruitenberg1,3,4 1School of Biomedical Sciences, University of Queensland, Brisbane, 4072, Australia, 2Wellcome Trust-Medical Research Council, Cambridge Stem Cell Institute & Department of Clinical Neurosciences, University of Cambridge, Cambridge, CB2 0AH, United Kingdom, 3Queensland Brain Institute, University of Queensland, Brisbane, 4072, Australia, and 4Trauma, Critical Care and Recovery, Brisbane Diamantina Health Partners, Brisbane, 4072, Australia
منابع مشابه
Cellular and Molecular Mechanisms Involved in Neuroinflammation after Acute Traumatic Spinal Cord Injury
Introduction: Spinal cord injury (SCI) following traumatic events is associated with the limited therapeutic options and sever complications, which can be partly due to inflammatory response. Therefore, this study aims to explore the role of inflammation in spinal cord injury. The findings showed that the pathological conditions of nervous system lead to activation of microglia, astrocyte, neut...
متن کاملMast cells protect from post-traumatic spinal cord damage in mice by degrading inflammation-associated cytokines via mouse mast cell protease 4
Mast cells (MCs) are found abundantly in the central nervous system and play a complex role in neuroinflammatory diseases such as multiple sclerosis and stroke. In the present study, we show that MC-deficient Kit(W-sh/W-sh) mice display significantly increased astrogliosis and T cell infiltration as well as significantly reduced functional recovery after spinal cord injury compared to wildtype ...
متن کاملA Review of the Occurrence and Mechanisms of Induction of Osteoporosis Following Spinal Cord Injury
Introduction: Spinal cord injury (SCI) causes devastating injuries in patients. The main mechanisms of the pathogenesis of secondary injury include nerve degeneration, gliosis, and inflammation. Spinal cord injury induces a disorder or failure in several organs due to the vital role of the spinal cord in regulating bodily functions. Osteoporosis is a consequence of spinal cord injury that occur...
متن کاملP167: Key Role of Inflammation in Central Nervous System Damage and Disease; TNFα, IL-1
Inflammation is portion of the body's immune response and it is basically a host protective response to tissue ischemia, injury, autoimmune responses or infectious agents. Although the information presented so far points to a detrimental role for inflammation in central nervous system (CNS) disease, it may also be useful. CNS demonstrates characteristic of inflammation, and in response to damag...
متن کاملTargeting acute inflammation to complement spinal cord repair
Immune effector mechanisms play key roles in the progressive (secondary) neurodegenerative changes that follow spinal cord injury (SCI). In our recent paper (Brennan et al., 2015), we showed that the inflammatory response to SCI includes rapid and robust activation of the innate immune complement system, with tissue levels of complement component 5a (C5a – an activation product generated by the...
متن کامل